Annual Business Planning

I decided to start fresh and reworked my email lists. I now have one full comprehensive email list of all my clients over the last three years and I also have segmented lists of my clients who are adult vacationers, family travelers, cruise specific clients, and my Disney clients. I really don't sell a lot of universal at this point. I am ready to start setting up my weekly emails, but I would also like to appeal to these different segments of client. How would you best inform these different segments? I was thinking that my weekly email can be a general email that informs clients about opportunities within certain locations. Then on the other hand if I do that, how do I send targeted emails to those specific segments without emailing people to death.